Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma

Zhang Xiaojiao Zhang Jun Wang Rui Guo Shicheng Zhang Huilu Ma Y. Liu Qingmei Chu Haiyan Xu Xianghong Zhang Yitong Yang D. Wang Jiucun Liu Jie · 2016

阅读量：157

去甲基化

肝细胞癌

甲基化

pnpla7

期刊名称：

Oncology Letters 2016 年 12 卷 1 期

发表日期：

2016.07.01

摘要：

Liver cancer has a high morbidity and mortality rate, and is one of the most common types of cancer in men. PNPLA7 is a member of the patatin-like phospholipase domain-containing protein family which is involved in triglyceride hydrolysis, energy metabolism and lipid droplet metabolism. The liver is the most important energy metabolism organ; whether PNPLA7 is deregulated in liver cancer has not been previously reported. In the present study, reverse transcription-quantitative polymerase chain reaction and subsequent methylation analysis provided evidence that PNPLA7 is down-regulated in hepatocellular carcinoma (HCC) cell lines and tissue samples, via the mechanism of transcriptional silencing by promoter hypermethylation. These results may provide novel insights for HCC diagnosis.