Does chromophobe renal cell carcinoma have better survival than clear cell renal cell carcinoma? A clinical-based cohort study and meta-analysis
Jiang Hui-Ming
Wei Jin-Huan
Zhang Zhi-Ling
Fang Yong
Zhou Bang-Fen
Chen Zhen-Hua
Lu Jun
Liao Bing
Zhou Fang-Jian
Luo Jun-Hang
Chen Wei
· 2016
期刊名称：
International Urology and Nephrology
2016 年
48 卷
2 期
摘要：
Background: It is controversial whether chromophobe renal cell carcinoma (chRCC) or clear cell renal cell carcinoma (ccRCC) is associated with better survival. We conducted a clinical-based cohort study and meta-analysis to evaluate the prognostic role of histology between chRCC and ccRCC. Methods: A cohort of 1540 patients (166 with chRCC and 1374 with ccRCC) were selected from Sun Yat-sen University and The Cancer Genome Atlas databases. The clinicopathological parameters and overall survival (OS) were compared between patients with chRCC and those with ccRCC. For the meta-analysis, we searched the PubMed, Cochrane Library, and Ovid databases for studies comparing OS or cancer-specific survival (CSS) between chRCC and ccRCC. Results: The cohort study revealed that patients with chRCC were younger (median 52 vs. 55??years, P??
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