A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy
Li Jingguo
Zhang Lu
Lin Yujie
Xiao Hong
Zuo Mingxiang
Cheng Du
Shuai Xintao
· 2016
期刊名称：
RSC Advances
2016 年
6 卷
11 期
摘要：
A novel tetra-doxorubicin-tailed polyethylene glycol via benzoic-imine bond linkage was synthesized and self-assembled to a pH-sensitive prodrug micelle. This micelle not only effectively entered cancer cells but also quickly released doxorubicin (DOX) in tumor sites to exert anticancer activity in vitro.
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