Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
Wu Chun-Yi
Wang Don-Hong
Wang Xiaobing
Dixon Seth M.
Meng Liping
Ahadi Sara
Enter Daniel H.
Chen Chao-Yu
Kato Jason
Leon Leonardo J.
Ramirez Laura M.
Maeda Yoshiko
Reis Carolina F.
Ribeiro Brianna
Weems Brittany
Kung Hsing-Jien
Lam Kit S.
· 2016
期刊名称：
ACS Combinatorial Science
2016 年
18 卷
6 期
摘要：
Identifying "druggable" targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molecules that bind to a specific target protein or elicit a specific cellular response. The phage display cDNA expression proteome library method has been employed to identify target proteins that interact with specific compounds. Here, we combined these two high-throughput approaches, efficiently interrogated approximately 10
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