Chromatographic efficiency comparison of polyhedral oligomeric silsesquioxanes-containing hybrid monoliths via photo- and thermally-initiated free-radical polymerization in capillary liquid chromatography for small molecules

Wang Hongwei Ou Junjie Liu Zhongshan Lin Hui Peng Xiaojun Zou Hanfa · 2015

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2-dimethoxy-2-phenylacetophenone

期刊名称：

Journal of Chromatography A 2015 年 1410 卷

发表日期：

2015.09.04

摘要：

Monolithic poly(methacrylate epoxy cyclosiloxane-. co-polyhedral oligomeric silsesquioxanes) (epoxy-MA-POSS) capillary columns have been prepared via either photo- or thermally-initiated polymerization of the corresponding monomers using a 1-propanol/PEG 400 mixture as porogens. Photochemical polymerization was accomplished by irradiation of the UV-transparent capillary for 10. min at room temperature, while thermal polymerization was performed at 55. ?°C, 60. ?°C or 65. ?°C for 18. h. The evaluation of chromatographic property for two hybrid epoxy-MA-POSS monoliths was carried out. The results indicate that hybrid monoliths fabricated by photochemical initiation exhibit higher column efficiency (97,000-98,400. plates/m) than those synthesized by thermal polymerization (41,100-48,000. plates/m) in cLC. The higher efficiency of photo-initiated hybrid monoliths is closely related to lower eddy dispersion (A-term) and mass transfer resistance (C-term).