Journal of Pharmaceutical Sciences   2016 年

2016.02.28

The concentration of maximally freeze-concentrated solutions W'g and the corresponding glass transition temperature T'g and ante-melting temperature T'm of lyoprotectant solutions, are critical parameters for developing lyophilization process. Usually, the lyoprotectant solutions are multicomponent solutions composed of electrolytes, sugars, proteins, polymers, and other chemicals. In this article, the Wg' values of several multicomponent solutions including trehalose/NaCl, bovine serum albumin/NaCl, and hydroxyethyl starch/NaCl with water were determined by differential scanning calorimetry. A linear relationship between the unfrozen water fraction W