Vimentin, a Novel NF-κB regulator, is required for meningitic Escherichia coli K1 - Induced pathogen invasion and PMN transmigration across the blood-brain barrier

Huang Sheng-He Chi Feng Peng Liang Bo Tao Zhang Bao Liu Li-Qun Wu Xuedong Mor-Vaknin Nirit Markovitz David M. Cao Hong Zhou Yan-Hong · 2016

阅读量：357

期刊名称：

PLoS ONE 2016 年 11 卷 9 期

发表日期：

2016.09.01

摘要：

Background: NF-??B activation, pathogen invasion, polymorphonuclear leukocytes (PMN) transmigration (PMNT) across the blood-brain barrier (BBB) are the pathogenic triad hallmark features of bacterial meningitis, but the mechanisms underlying these events remain largely unknown. Vimentin, which is a novel NF-??B regulator, is the primary receptor for the major Escherichia coliK1 virulence factor IbeA that contributes to the pathogenesis of neonatal bacterial sepsis and meningitis (NSM). We have previously shown that IbeA-induced NF-??B signaling through its primary receptor vimentin as well as its co-receptor PTB-associated splicing factor (PSF) is required for pathogen penetration and leukocyte transmigration across the BBB. This is the first in vivo study to demonstrate how vimentin and related factors contributed to the pathogenic triad of bacterial meningitis. Methodology/Principal Findings: The role of vimentin in IbeA