International Journal of Clinical and Experimental Pathology   2016 年 9 卷 3 期

2016

MicroRNAs (miRNAs) play important roles in various cancers, are associated with tumor genesis, progression and prognosis. MiR-378 has important roles in inhibiting gastric cancer cell proliferation, migration and invasion. However, the relationships between miR-378 expression and clinicopathological features, and prognosis are not yet investigated. In this study, we investigated the expression of miR-378 in 87 pairs of primary gastric cancer and their corresponding nontumorous tissues, and analyzed its clinical significance. The study showed that miR- 378 was frequently downregulated in gastric cancer, and the reduced expression of miR-378 was associated with increased local tumor invasion and advanced stages. Patients with lymph node metastasis displayed a lower miR- 378 expression than gastric cancer without lymph node metastasis. Univariate analysis identified low expression of miR-378 as a poor prognostic factor. These results suggest that miR-378 has a potential to serve as a clinical biomarker for predicting disease invasiveness and prognosis of patients with gastric cancer.