Knockout of interleukin-17A protects against sepsis-associated acute kidney injury
Luo Cong-juan
Luo Feng
Zhang Li
Xu Yan
Cai Guangyan
Fu Bo
Feng Zhe
Sun Xuefeng
Chen Xiangmei
· 2016
期刊名称：
Annals of Intensive Care
2016 年
6 卷
1 期
摘要：
Background: Sepsis-associated acute kidney injury (SA-AKI) is an independent risk factor for death in patients with sepsis, but treatment for it is limited. To improve the diagnosis and treatment of SA-AKI, we must first understand its pathogenesis. Recently, interleukin (IL)-17A has been shown to be associated with the pathogenesis of acute kidney injury and sepsis, but its role in SA-AKI remains unclear. Methods: SA-AKI was induced in male C57BL/6 and IL-17A
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