RICTOR polymorphisms affect efficiency of platinum-based chemotherapy in Chinese non-small-cell lung cancer patients
Wang Shiming
Song Xiao
Li Xiaoying
Zhao Xueying
Chen Hongyan
Wang Jiucun
Wu Junjie
Gao Zhiqiang
Qian Ji
Han Baohui
Bai ChunXue
Li Qiang
Lu Daru
· 2016
期刊名称：
Pharmacogenomics
2016 年
17 卷
15 期
摘要：
Aim: We investigated the association between RICTOR polymorphisms and clinical outcomes of platinum-based chemotherapy for Chinese non-small-cell lung cancer patients. Materials & methods: Ten tag SNPs were genotyped in 1004 patients to assess their association with clinical benefit, overall survival, progression-free survival, gastrointestinal toxicity, neutropenia, anemia and thrombocytopenia. Results: rs6878291 was significantly associated with clinical benefit (odds ratio: 2.037; p = 0.001) and reduced progression-free survival (hazard ratio: 1.461; p = 0.001). Stratified analysis showed that their most significant interaction was in nonsmokers. No association was observed between SNPs and other clinical outcomes. Conclusion: The study showed evidences for RICTOR polymorphisms' role in platinum-based chemotherapy efficiency, which could provide new insight to lung cancer management.
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