Pest Management Science   2016 年 72 卷 4 期

2016.04.01

BACKGROUND: 1??, 2??, 4?±, 6?±, 8??, 9?±, 12-hepthydroxyl-??-dihydroagarofuran is the main skeleton of ??-dihydroagarofuran sesquiterpenoids, which exhibit excellent insecticidal activity. To study further the structure-activity relationship of ??-dihydroagarofuran sesquiterpenoids towards finding novel botanical pesticides, two series of new structurally modified ether analogues were designed and synthesised, and their insecticidal activities were evaluated. RESULTS: Twenty-two ether derivatives were synthesised using 1??, 2??, 4?±, 6?±, 8??, 9?±, 12-hepthydroxyl-??-dihydroagarofuran as starting material. Bioassay results indicated that most of the derivatives, particularly compounds 5.1.2, 5.1.3, 5.1.7, 5.2.3, 5.2.6 and 5.2.7, exhibited significant insecticidal activity against the third-instar larvae of the oriental armyworm Mythimna separata. Most importantly, compound 5.2.7 showed the lowest LD