The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice
Zhu Xiaobo
Yin Junjie
Liang Sihui
Liang Ruihong
Zhou Xiaogang
Chen Zhixiong
Zhao Wen
Wang Jing
Li Weitao
He Min
Yuan Can
Miyamoto Koji
Ma Bingtian
Wang Jichun
Qin Peng
Chen Weilan
Wang Yuping
Wang Wenming
Wu Xianjun
Yamane Hisakazu
Li Shigui
Chen Xue-Wei
· 2016
期刊名称：
PLoS Genetics
2016 年
12 卷
9 期
摘要：
Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice. Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice. Disruption of LRD6-6 leads to enhanced immunity and cell death in rice. The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. An ATPase inactive mutation (LRD6-6
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