Analysis of liposoluble carboxylic acids metabolome in human serum by stable isotope labeling coupled with liquid chromatography–mass spectrometry
Zhu Quan-Fei
Zhang Zheng
Liu Ping
Zheng Shu-Jian
Peng Ke
Deng Qian-Yun
Zheng Fang
Yuan Bi-Feng
Feng Yu-Qi
· 2016
期刊名称：
Journal of Chromatography A
2016 年
1460 卷
摘要：
Fatty acids (FAs) are groups of liposoluble carboxylic acids (LCAs) and play important roles in various physiological processes. Abnormal contents or changes of FAs are associated with a series of diseases. Here we developed a strategy with stable isotope labeling combined with liquid chromatography??“tandem mass spectrometry (IL??“LC??“MS) analysis for comprehensive profiling and relative quantitation of LCAs in human serum. In this strategy, a pair of isotope labeling reagents (2-dimethylaminoethylamine (DMED)) and d
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