Activation of ERK1/2 and TNF-α production are regulated by calcium/calmodulin signaling pathway during Penicillium marneffei infection within human macrophages
期刊名称：
Microbial Pathogenesis
2016 年
93 卷
摘要：
Previous study have shown that Penicillium marneffei (P. marneffei)-induced TNF-?± production via an extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase-dependent mechanism is an important host defence mechanism against P. marneffei in human macrophages. Therefore, we explore signaling pathway that regulates TNF-?± secretion and activation of ERK1/2 by intracellular signaling mechanisms during P. marneffei infection. We found that ERK1/2 activation was dependent on the calcium/calmodulin/calmodulin kinase ?± pathway in P. marneffei-infected human macrophages. In contrast, P. marneffei-induced p38 MAPK activation was negatively regulated by calcium/calmodulin/calmodulin kinase ?± signaling pathway. Furthermore, TNF-?± production in P. marneffei-infected human macrophages was also dependent on Ca
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