Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells
Liang Nan
Zhong Rui
Hou Xue
Zhao Gang
Ma Shumei
Cheng Guanghui
Liu Xiaodong
· 2015
期刊名称:
Cell Proliferation
2015 年
48 卷
5 期
摘要:
Objectives: The role of Ataxia-telangiectasia mutated (ATM) in response to DNA damage has previously been studied, but its underlying mechanisms specific to ionizing radiation (IR) have remained to be elucidated. In this study, function of ATM on radiation-induced cell death in lung cancer H1299 cells was analysed. Materials and methods: Human lung cancer cells, H1299, were used, and cell models with ATM