Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A
Ren Weiguo
Shen Shourong
Sun Zhenqiang
Shu Peng
Shen Xiaohua
Bu Chibin
Ai Feiyan
Zhang Xuemei
Tang Anliu
Tian Li
Li Guiyuan
Li Xia-Yu
Ma Jian
· 2016
期刊名称：
Cancer Letters
2016 年
375 卷
2 期
摘要：
Chronic intestinal inflammation is closely associated with colon cancer development and STAT3 seems to take center stage in bridging chronic inflammation to colon cancer progress. Here, we discovered that DICER1 was significantly downregulated in response to IL-6 or LPS stimulation and identified a novel mechanism for DICER1 downregulation via proteasomal degradation by ubiquitin ligase complex of CUL4A
会员登录
