The polymorphisms of MSH6 gene are associated with AIDS progression in a northern Chinese population
Wang Chuntao
Zhao Chunyan
Zhang X.
Xu Lidan
Jia Xueyuan
Sun Haiming
Yu Jingcui
Zhang Guangfa
He Ning
Li Qiuyan
Qiao Yuandong
Fu Song-Bin
· 2016
期刊名称：
Infection, Genetics and Evolution
2016 年
42 卷
摘要：
It has been reported that DNA repair genes play an important role in HIV-1 infection and AIDS progression. One DNA repair pathway, the mismatch repair (MMR) is associated with a wide variety of tumors. However, the role of single nucleotide polymorphisms (SNPs) in the MMR genes and their importance in HIV-1 infection and AIDS progression remain unclear. In the present study, 479 HIV-1-infected and 487 healthy individuals from northern China were genotyped for nine SNPs in the MSH2 gene (rs13019654, rs4608577, rs4952887, rs6726691, rs10191478, rs12999145, rs1981929, rs2042649, rs2303428) and five SNPs in the MSH6 gene (rs2348244, rs3136245, rs3136329, rs2072447, rs7562048). Our results showed that the rs7562048 G allele frequency was significantly higher in the cases with the CD4
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