Two new quinic acid derivatives and one new lignan glycoside from Erycibe obtusifolia

Feng Zi-Ming Liu Zhao-zhen Yang Peng-fei Yang Ya-Nan Jiang Jian-Shuang Zhang Pei-Cheng · 2016

阅读量：55

酰苷

细胞毒活性

丁公藤

奎尼酸衍生物

期刊名称：

Phytochemistry Letters 2016 年 17 卷

发表日期：

2016.09.01

摘要：

Three new compounds, 4-{erythro-2-[3-(4-hydroxyl-3-methoxyphenyl)-3-O-??-D-glucopyranosyl-propan-1-ol]}-O-medioresinol (1), (7???E,9???E,1???R*,3???S*,5???R*,6???S*)-5-O-caffeoyl-3-O-dihydrophaseicoylquinic acid (2), and (7???E,9???E,1???R*,3???S*,5???R*,6???S*)-5-O-caffeoyl-4-O-dihydrophaseicoylquinic acid (3), were isolated from Chinese folk herb Erycibe obtusifolia together with six known compounds (4??“9). Their structures were elucidated on the basis of comparisons of literatures and extensive spectroscopic analysis, including UV, IR, HRMS, and 1D and 2D NMR techniques. Further, the cytotoxicities of these compounds were evaluated against five cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780), but they were inactive against these tumor cell lines (IC