Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

Tang Clara S. Zhang He Cheung Chloe Y.Y. Xu Ming Ho Jenny C.Y. Zhou Wei Cherny Stacey S. Zhang Yan Holmen Oddgeir Au Ka-Wing Yu Haiyi Xu Lin Jia Jia Porsch Robert M. Sun Lijie Xu Wei-Xian Zheng Huiping Wong Lai-Yung Mu Yi-Ming Dou Jingtao Fong Carol H. Y. Hong Xueyu Lam Levina S.M. Su Xi Yan Hua Yang Min-Lee Chen Jin Siu Chung-Wah Woo Y.C. Wu Yangfeng Tan Kathryn Choon-Beng Hveem Kristian Cheung Bernard Man-Yung Z?llner Sebastian Xu Aimin Chen Y. Eugene Zhang Youyi Lam Tai Hing Ganesh Santhi K. Huo Yong Sham Pak Chung Lam Karen S.L. Willer Cristen J. Tse Hung-Fat Gao Wei · 2015

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遗传协会

期刊名称：

Nature Communications 2015 年 6 卷

发表日期：

2015.12.22

摘要：

Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 ?— 10