3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation

Shi Wei-Kang Deng Rui-Cheng Wang Peng-Fei Yue Qin-Qin Liu Qi Ding Kun-Ling Yang Mei-Hui Zhang Hong-Yu Gong Si-Hua Deng Min Liu Wen-Run Feng Qiu-Ju Xiao Zhu-Ping Zhu Hai-Liang · 2016

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3-arylpropionylhydroxamic酸

期刊名称：

Bioorganic and Medicinal Chemistry 2016 年 24 卷 19 期

发表日期：

2016.10.01

摘要：

Helicobacter pylori urease is involved in several physiologic responses such as stomach and duodenal ulcers, adenocarcinomas and stomach lymphomas. Thus, inhibition of urease is taken for a good chance to treat H. pylori-caused infections, we have therefore focused our efforts on seeking novel urease inhibitors. Here, a series of arylpropionylhydroxamic acids were synthesized and evaluated for urease inhibition. Out of these compounds, 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropionylhydroxamic acid (d24) was the most active inhibitor with IC