Comprehensive profiling of ribonucleosides modification by affinity zirconium oxide-silica composite monolithic column online solid–phase microextraction – Mass spectrometry analysis
Jiang Han-Peng
Chu Jie-Mei
Lan Meng-Dan
Liu Ping
Yang Na
Zheng Fang
Yuan Bi-Feng
Feng Yu-Qi
· 2016
期刊名称：
Journal of Chromatography A
2016 年
1462 卷
摘要：
More than 140 modified ribonucleosides have been identified in RNA. Determination of endogenous modified ribonucleosides in biological fluids may serve as non-invasive disease diagnostic strategy. However, detection of the modified ribonucleosides in biological fluids is challenging, especially for the low abundant modified ribonucleosides due to the serious matrix interferences of biological fluids. Here, we developed a facile preparation strategy and successfully synthesized zirconium oxide-silica (ZrO
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