A Decade Effort of PTM Bioinformatics for Epigenetic Modifications

薛宇 Shuang Zhang Wankun Deng Yu Xue · 2017

阅读量：363

会议名称：

中国生物工程学会第二届青年科技论坛暨首届青年工作委员会学术年会

会议时间：

2017-04-08 00:00:01

会议地点：

中国广东广州

摘要：

<正>As an important epigenetic mechanism,post-translational modifications(PTMs)of histones or histone modifications combinatorially and dynamically constitute?histone code‘,which accurately regulates a variety of DNA-templated processes.such as gene transcription,chromosome segregation and DNArepair.Acetylation and methylation are two predominant types of histone modifications.Histone acetylation neutralizes the positive charges of lysine residues,