Adenosine analogs as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and antibacterial evaluation
Wei Wei
Shi Wei-Kang
Wang Peng-Fei
Zeng Xiao-Tong
Li Pan
Zhang Ji-Rong
Li Qian
Tang Zhi-Ping
Peng Jia
Wu Lang-Zhou
Xie Mei-Qun
Liu Chan
Li Xian-Hui
Wang Ying-Chun
Xiao Zhu-Ping
Zhu Hai-Liang
· 2015
期刊名称：
Bioorganic and Medicinal Chemistry
2015 年
23 卷
20 期
摘要：
Herein we describe the synthesis and evaluation of a series of adenosine analogs for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Out of these compounds, compound c6 has much stronger antibacterial potency against Pseudomonas aeruginosa than ciprofloxacin, and was determined to target tyrosyl-tRNA synthetase with IC
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