摘要：
Objective The objective of this study was to estimate the risk of a seizure relapse and the high-risk period of recurrence after antiepileptic drug (AED) withdrawal and to determine the predictive factors for a seizure relapse in adult patients with focal epilepsy who were seizure-free for more than 2??years. Methods Using the Wenzhou Epilepsy Follow-Up Registry Database, 200 adult patients with focal epilepsy were recruited, who were undergoing follow-up, met the inclusion criteria of this study, were seizure-free for more than 2??years, began withdrawing between June 2003 and June 2014, and were followed up prospectively for at least 1??year or until a seizure relapse. The risk of recurrence and the time to seizure relapse were analyzed by the Kaplan??“Meier method, and the predictive factors were identified by the Cox proportional hazard regression model. Result A total of 99 patients had an unprovoked relapse during the follow-up period. The relapse rate was 49.5%, and each year, the recurrence probability of 12, 24, 36, 48, 60, 72, and 84??months after AED withdrawal was 24.0%, 20.4%, 8.3%, 2.7%, 4.6%, 0.97%, and 0.98%, respectively. The two independent risk factors for recurrence after withdrawal in adult patients with focal epilepsy were a longer duration of active epilepsy and a shorter seizure-free period before withdrawal. Conclusion The high-risk period of a seizure relapse in adult patients with focal epilepsy is the first 2??years after withdrawal, and beyond 5??years after withdrawal, seizures rarely relapse (relapse rate??
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