Molecular targeted magnetic resonance imaging of human colorectal carcinoma (lovo) cells using novel superparamagnetic iron oxide- loaded nanovesicles: In vitro and in vivo studies
Feng Shi-Ting
Li Hao
Luo Yanji
Cai Huasong
Dong Zhi
Fang Zhuangnian
Shuai Xintao
Li Zi Ping
· 2016
期刊名称：
Current Cancer Drug Targets
2016 年
16 卷
6 期
摘要：
Objective: To investigate the feasibility of superparamagnetic iron oxide (SPIO) nanoparticles (SPIO) as a magnetic resonance (MR) contrast agent to enhance tumor imaging in vivo. Methods: Hydrophobic SPIO (oil-soluble SPIO; OSPIO) and hydrophilic SPIO (water-soluble SPIO; WSPIO) were loaded in methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PDLLA) nanovesicles. Three groups of nude mice (n=12/group) xenografted with human colorectal carcinoma (LoVo) cells were injected into the caudal vein with WSPIO, OSPIO-loaded nanovesicles, or WSPIO-loaded nanovesicles. MRI scans were performed on all of the mice, and the relative T
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