Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis

Lin Runhua Zhang Chong Zheng Jiaxuan Tian Dongping Lei Zhijin Chen Donglin Xu Zexin Su Min · 2016

阅读量：65

慢性炎症

期刊名称：

Oncotarget 2016 年 7 卷 17 期

发表日期：

2016.04.26

摘要：

Chronic inflammation is associated with increased risk of cancer development, whereas the link between chronic inflammation and esophageal carcinogenesis is still obscure heretofore. This study aimed to investigate the relationship between chronic inflammation and DNA damage, as well as the possible role of DNA damage in esophageal carcinogenic process. Endoscopic esophageal biopsies from 109 individuals from Chaoshan littoral, a high-risk region for esophageal squamous cell carcinoma (ESCC), were examined to evaluate the association between chronic inflammation and histological severity, while additional 204 esophageal non-tumor samples from patients with ESCC were collected. Immunohistochemistry was performed to detect the oxidative DNA damage and DNA double-strand breaks (DSBs). Significantly positive correlation was observed between degree of chronic inflammation and esophageal precursor lesions (r