One-Pot Synthesis of 4-Heteroaryl-Substituted Pyrazoles: A Gold-Catalyzed Oxidation/1,2-Heteroaryl Migration Cascade Constitutes the Key Step

Yao Xinbo Wang Tao Zhang Xi Wang Ping Zhang Bing Wei Jun-Fa Zhang Zunting · 2016

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3-Diketones

期刊名称：

Advanced Synthesis and Catalysis 2016 年 358 卷 9 期

发表日期：

2016.04.28

摘要：

An efficient gold-catalyzed oxidation/1,2- heteroaryl migration cascade leading to 2-heteroaryl-substituted 1,3-diketones and its further application in the one-pot synthesis of 4-heteroaryl-substituted pyrazoles and the preparation of 4-heteroaryl-substituted isoxazoles are reported. A wide variety of 4-heteroaryl-substituted pyrazoles were obtained, indicating the broad substrate scope and functional group tolerance of this method.