Combination of microbubbles and diagnostic ultrasound at a high mechanical index for the synergistic microwave ablation of tumours

Xu Jinshun Cao Yang Xu Chunyan Cheng Xueqing You Yufeng Yao Yuanzhi Liu Jianxin Wang Zhigang Li Pan Lu Min · 2016

阅读量：286

癌症

造影剂

热消融

超声成像

期刊名称：

International Journal of Hyperthermia 2016 年

发表日期：

2016.10.18

摘要：

Objectives: To determine whether combining microbubbles (MBs) with diagnostic ultrasound (US) at a high mechanical index (MI) could enhance the microwave (MW) ablation of tumours. Materials and methods: Five therapeutic MW adjuvant protocols were studied: MW, MW??‰+??‰US, MW??‰+??‰US??‰+??‰MB, MW??‰+??‰US??‰+??‰NS (saline) and MW??‰+??‰MB. In 30 normal rabbit livers, the synergistic effects were evaluated via temperature, necrosis volume and histology. In 90 VX2 rabbit hepatic tumours, residual cells in the peripheral ablated tumours were examined via immunohistochemical assay and tumour growth. Additional 40 VX2 hepatic tumours were evaluated for ablation safety via blood assay and weight and for survival to 105 days. Results were compared using analysis of variance. Results: Compared with the other protocols, the ablation volumes in normal rabbit livers were significantly larger using the MW??‰+??‰US??‰+??‰MB protocol (p??‰