Expression pattern and regulation of miR-19a and CCND1 IN C3H10T1/2 chondrogenic differentiation

Gong Ming Ma Yan-Ling Letu Geri Wang Hong Huang Tian-Hua Ni Hua-Wei Wu Ming-Jie Zhou Zhen-Quan Li Min Zou Xue-Nong · 2016

阅读量：384

软骨分化

间充质干细胞

microRNA

期刊名称：

International Journal of Clinical and Experimental Medicine 2016 年 9 卷 7 期

发表日期：

2016.07.30

摘要：

Mesenchymal stem cells are regulated by many different pathways even in early stage of chondrogenic differentiation that the cells??? proliferation is depressed. Recent studies have supplied marker genes of chondrogenesis were potently affected by cell cycle alterations. In this study, we explored relationship between miR-19a and CCND1, a cell cycle gene, in chondrogenic differentiation and revealed the possible mechanism of miR-19a engaging in its proliferation. A cell pellet model was applied to induce chondrogenesis in C3H10T1/2 cells. In the experiment, chondrogenic differentiation was induced by TGF-??