Heat-Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette-Guérin Vaccine
Ding Yun
Zheng H.
Feng C.
Wang B.
Liu C.
Mi K.
Cao Hongwei
Meng Songdong
· 2016
期刊名称：
Scandinavian Journal of Immunology
2016 年
84 卷
4 期
摘要：
The commonly used Bacillus Calmette-Gu??rin (BCG) vaccine only induces moderate T cell responses and is less effective in protecting against pulmonary tuberculosis (TB) in adults and ageing populations. Thus, developing new TB vaccine candidates is an important strategy against the spread of Mycobacterium tuberculosis. Here, we demonstrated that immunization with heat-shock protein gp96 as an adjuvant led to a significantly increased CD4
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