Hypofibrinogenemia as a clue in the presumptive diagnosis of acute promyelocytic leukemia

Lou Yinjun Suo Shanshan Tong Hongyan Qian Wenbin Mai Wenyuan Meng Haitao Yu Wenjuan Wei Juyin Jin Jie · 2016

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急性早幼粒细胞白血病

早期死亡

纤维蛋白原

初步诊断

期刊名称：

Leukemia Research 2016 年 50 卷

发表日期：

2016.11.01

摘要：

Acute promyelocytic leukemia (APL) is a medical emergency. In order to evaluate the usefulness of initial coagulation parameters in the predictive value of APL diagnosis, 1304 consecutive newly diagnosed acute leukemia patients, including APL (n??=??211), non-APL acute myeloid leukemia (n??=??781) and acute lymphoblastic leukemia (n??=??312) were retrospectively evaluated between January 2011 and May 2015. The area under curve (AUC) of fibrinogen was the largest among the coagulation markers based on receiver operating characteristic (ROC) analysis. The optimum cutoff value of fibrinogen was 1.87??g/L (AUC??=??0.912, sensitivity 80.1% and specificity 88.8%). The optimum cutoff value of D-dimer was 2191????g/L (AUC??=??0.786, sensitivity 81.1% and specificity 67.8%). The AUC difference between the fibrinogen and D-dimer was significant (P??